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The Arnold Lab

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Microbiome and Healthy Aging

We study how the microbiome influences healthy aging, using animal models to uncover its role in extending healthspan and resilience. By exploring host-microbe interactions, my work aims to identify microbial strategies that promote longevity and well-being across species.

How can microbiomes contribute to healthy aging?

Can microbiome serve as a modulator of neurodegenerative disease?

How can microbiomes contribute to healthy aging?

We are developing translational animal models of rapid aging to investigate how host-microbiome interactions influence healthspan. By leveraging these models, we aim to identify microbial factors that promote resilience and longevity, ultimately guiding strategies to improve healthy aging across species.

How do we build resilient microbiomes?

Can microbiome serve as a modulator of neurodegenerative disease?

How can microbiomes contribute to healthy aging?

We explore how the microbiome contributes to resilience and chronic pain modulation, investigating its role in stress response, inflammation, and recovery. By studying host-microbe interactions, we aim to uncover microbial factors that influence pain sensitivity and resilience.

Can microbiome serve as a modulator of neurodegenerative disease?

Can microbiome serve as a modulator of neurodegenerative disease?

Can microbiome serve as a modulator of neurodegenerative disease?

Preliminary evidence suggests that there are common microbial clades which link to the presence of neurodegenerative disease and associate with decreased cognitive performance in mice. Surprisingly, some microbial features tend to associate with improved cognitive function despite the presence or absence of a neurodegenerative condition.

Wild Microbiomes

We investigate microbiomes in wild host systems to understand how microbes shape health, resilience, and adaptation in natural environments. By studying host-microbe interactions in wildlife, my work explores the ecological and evolutionary forces that drive microbial diversity and function.

How do microbiomes contribute to fitness in Desert Bighorn Sheep

How do microbiomes contribute to fitness in Desert Bighorn Sheep

How do microbiomes contribute to fitness in Desert Bighorn Sheep

We are interested in characterizing how the microbiome influences health and fitness in desert bighorn sheep by examining its role in immune function, disease resistance, nutrition, and overall physiological resilience. 

Aquatic Microbiome for Sustainable food Production

How do microbiomes contribute to fitness in Desert Bighorn Sheep

How do microbiomes contribute to fitness in Desert Bighorn Sheep

We are also investigating how the microbiome influences health and survival in salmon, particularly in relation to pre-spawn mortality.  It is our hope that this research could help inform strategies to improve survival rates and sustainability in both wild and aquaculture salmon populations.

Wild Microbiomes of Marine Mammals

How do microbiomes contribute to fitness in Desert Bighorn Sheep

Wild Microbiomes of Marine Mammals

California sea lions, a sentinel species, help us to understand how environmental and microbial factors influence health and disease in marine ecosystems. By characterizing the microbiome's role in immune function, toxin metabolism, and disease susceptibility, our research seeks to provide insights into both sea lion health and broader oceanic health trends.

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